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The 1,4-Dioxane Book

The Complete Reference
Chapter 5 – Table of Contents
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Chapter 5       The Toxicology of 1,4-Dioxane (by Julie Stickney, Ph.D., DABT, Syracuse Research Corporation)
5.1 Toxicokinetics
5.2 Toxicity Studies in Humans
5.3 Toxicology Studies in Laboratory Animals
5.3.1 Acute and Short-Term Toxicity Studies (<1 Month Exposure)
5.3.2 Subchronic and Chronic Toxicity Studies
5.3.3 Mechanistic Toxicology Studies
5.3.3.1 Genotoxicity
5.3.3.2 Initiation/Promotion Studies
5.3.3.3 Mechanistic Studies Evaluating Mode of Action for Carcinogenicity
5.4 Summary of Noncancer Health Effects
5.5 Characterization of Cancer Potential
5.5.1 Summary of Human and Animal Data
5.5.2 Weight-of-Evidence Evaluation
5.5.3 Mode of Action
5.6 1,4-Dioxane Toxicology and Risk Assessment